What is the Paleo Diet, Unlock its Benefits for Better Health

What is the Paleo Diet

The paleo diet is an eating plan inspired by foods consumed during the Paleolithic Era. Paleolithic people are the founder of the paleo diet. It focuses on whole foods obtained through hunting and gathering, such as fruits, vegetables, lean meats, fish, eggs, nuts, and seeds. It excludes foods introduced with farming, such as grains, legumes, and dairy products. Also known as the Stone Age or hunter-gatherer diet, its purpose is to align with early human diets, arguing that modern dietary changes outpace human adaptation, potentially contributing to obesity, diabetes, and heart disease. People may follow it to manage weight or reduce heart disease risk factors.

Paleo Diet Review

According to a journal published at

PubMed Central®
PubMed Central®
Highly respected database from the National Institutes of Health
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, young people from industrialized societies reveal higher rates of obesity, hypertension, insulin resistance, type 2 diabetes and atherosclerosis among the former. Modern diets and lifestyles diverge significantly from those for which human metabolism evolved. Key differences include chemically treated vegetables, high-fat domesticated meats, and widespread physical inactivity. Wild animal meat, consumed by early humans, contained less than 4% lipids and higher levels of unsaturated fatty acids, unlike domesticated meat, which has 25–30% lipids and more saturated fats.

Human brain development relies on long-chain polyunsaturated fatty acids (PUFAs) like DHA and AA, found in seafood and plant foods. Early Homo’s gut morphology reflects an adaptation to easily digestible animal foods rather than plant-heavy diets, correlating with increased brain size, height, and metabolic health. The dominance of processed foods, dairy, cereals, refined sugars, and oils in modern Western diets that contains ultra processed foods is linked to an epidemic of chronic diseases and poor metabolic health, stemming from a mismatch between contemporary food and Paleolithic DNA. The Paleolithic diet is estimated to have consisted of 37% protein, 41% carbohydrates, and 22% fat.

The average American diet consists of approximately 50% carbohydrates, 33% fat, and 15% protein, with significant reliance on processed foods contributing to 77% of dietary salt intake. In contrast, the Paleolithic diet (PD) was richer in vitamins, minerals, and healthier fat ratios, maintaining a 1:1 balance of n-6 to n-3 fatty acids compared to today’s 10:1 ratio, which promotes inflammation.

Paleo Diet improves health outcomes, including reductions in:

  • weight
  • BMI
  • waist circumference
  • blood pressure

Even outperforming the Mediterranean diet in managing glucose tolerance and cardiovascular risk factors. However, modern challenges to adopting the PD include the scarcity of wild animal meat, potential negative effects of high-protein consumption without adequate unsaturated fats, and environmental toxin risks like methylmercury from increased fish consumption. These factors highlight both the benefits and limitations of adapting a PD in contemporary settings.

How is the Paleo Diet is differ from our Earlier Generations

Earlier generations’ diet included 30-35% meat and seafood, contrasting sharply with modern vegan or vegetarian diets. The prevalence of processed foods, refined sugars, unhealthy fats, and excessive red meat in today’s diets is linked to modern diseases. A balanced diet—including moderate meat, seafood, nuts, vegetables, and fruits—is suggested as healthier than eliminating animal products entirely.

Key nutrients like DHA, vitamin B12, heme iron, collagen, chondroitin, and glucosamine vital for brain, joint, bone, and skin health. These are found primarily in animal-based foods and are difficult or impossible to obtain from plants. These nutrients should ideally come from diet rather than supplements. While life expectancy increased with advancements during the Agricultural Revolution, the human genome evolved on a balanced diet more reflective of Paleolithic eating habits, emphasizing the importance of equilibrium in nutrition for long-term health.

Table with fresh fruits, vegetables, lean meats, nuts, and seeds arranged neatly, with a natural green background and sunlight -  NutriAdvise.com
Here's a detailed breakdown of foods typically included and excluded, typically the rules of the paleo diet, supported by scholarly sources:

Foods on the Paleo Diet:  

  1. Lean Meats: Emphasis on grass-fed and pasture-raised meats, which are believed to have a more favorable fatty acid profile compared to conventionally raised livestock.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  2. Fish and Seafood: Particularly those rich in omega-3 fatty acids, such as wild-caught fish, aligning with the presumed nutrient intake of early human diets.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  3. Fruits and Vegetables: A diverse range of non-starchy vegetables and fruits, providing essential vitamins, minerals, and fiber, consistent with the plant-based components of ancestral diets.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  4. Nuts and Seeds: Including almonds, walnuts, and sunflower seeds, which offer healthy fats and protein, mirroring the foraged foods of hunter-gatherer societies.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  5. Eggs: Consumed as a source of protein and nutrients, reflecting the inclusion of foraged animal products in early human diets.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  6. Healthy Fats: Such as those from nuts and seeds, aligning with the lipid profiles of natural foods available in the Paleolithic era.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source

Avoid on the Paleo Diet:

  1. Grains: (e.g., wheat, rice, barley, corn) were introduced post-agriculture and contain antinutrients like phytic acid and lectins, which may hinder nutrient absorption.
    PubMed®
    PubMed®
    Highly respected database from the National Institutes of Health
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  2. Legumes: (e.g., beans, lentils, soy, peanuts) also contain anti-nutrients and were not part of pre-agricultural diets. Their lectins and phytic acid content can interfere with digestion and nutrient uptake.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  3. Dairy Products: (e.g., milk, cheese, butter, yogurt) began after the domestication of animals, and many humans have limited lactase persistence, leading to lactose intolerance.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  4. Processed Foods: (e.g., packaged snacks, refined sugars) introduces additives, preservatives, and high levels of refined sugars, which are absent in ancestral diets.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  5. Refined Oils: (e.g., soybean oil, canola oil, corn oil) are highly processed and contain high omega-6 fatty acid levels, which can contribute to inflammation.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  6. Salt (High Sodium Levels): Salt are a modern dietary phenomenon and were not prevalent in ancestral diets, which had much lower sodium content.
    PubMed®
    PubMed®
    Highly respected database from the National Institutes of Health
    Go to source
  7. Alcohol: Alcohol was not consumed during the Paleolithic era, and its inclusion is inconsistent with the diet’s premise.
    PubMed Central®
    PubMed Central®
    Highly respected database from the National Institutes of Health
    Go to source
  8. Sugary Beverages: (e.g., sodas, fruit juices) are high in refined sugars and provide empty calories, contributing to metabolic syndrome and other health issues.
    PubMed®
    PubMed®
    Highly respected database from the National Institutes of Health
    Go to source

Benefits of the Paleo Diet

Role of Paleo Diet in Preventing Non Alcoholic Fatty Liver Disease

According to a study published at

PubMed Central®
PubMed Central®
Highly respected database from the National Institutes of Health
Go to source
, The potential health benefits of Paleo Diet (PD) are attributed to its high intake of fruits, vegetables, fish, nuts, and its avoidance of processed foods, added sugars, salt, and vegetable oils. This nutrient-rich diet provides antioxidants, fibers, healthy fats, and essential vitamins, which contribute to its protective role against conditions like non-alcoholic fatty liver disease (NAFLD). Studies indicate that a diet high in wholesome, unprocessed foods and low in calorie-dense, refined, and saturated-fat-rich foods is inversely associated with NAFLD risk.

Unhealthy dietary patterns characterized by high consumption of processed foods, red meat, and refined grains, alongside cooking practices like high-temperature meat preparation, contribute to NAFLD development through oxidative stress and insulin dysregulation. In contrast, the PD regulates insulin signaling, improves insulin resistance and lipid profiles, and reduces fructose intake, which are all protective against non-alcoholic fatty liver disease.

Additionally, a Paleolithic lifestyle, including regular physical activity, maintaining a healthy BMI, and avoiding smoking, further reduces NAFLD risk, highlighting the importance of a holistic approach to prevention. Obesity, sedentary behavior, and smoking are key contributing factors to non-alcoholic fatty liver disease alongside diet.

Role of Paleo Diet in reducing the risk of stress, anxiety and depression

According to a study published at
PubMed Central®
PubMed Central®
Highly respected database from the National Institutes of Health
Go to source
, Paleo diet appears to be beneficial for mental health, potentially reducing the risk of depression, anxiety, and stress.

Key Mechanisms of the Paleo Diet
  • Anti-inflammatory and Antioxidant Properties: The diets include foods rich in antioxidants (e.g., fruits, vegetables, nuts), which reduce inflammation and oxidative stress, key factors linked to psychological disorders.
  • Prebiotic Fibers: High fiber intake supports gut health by promoting a balanced microbiome, positively impacting the gut-brain axis and mental health.
  • Essential Micronutrients: Nutrients like magnesium, folic acid, and vitamin C enhance brain function, neurotransmitter synthesis, and reduce depression symptoms.
  • Healthy Fats: Higher intake of monounsaturated and polyunsaturated fatty acids (e.g., n-3 PUFAs) supports brain function and reduces neuroinflammation.
  • Reduced Saturated Fats: Low saturated fat consumption helps avoid neuroinflammation and supports overall brain health.

Key Notes to Remember

While the Paleo diet promotes the intake of nutrient-rich foods, it can be limiting and may result in potential nutrient deficiencies. It is recommended to consult a healthcare provider or registered dietitian before implementing major dietary changes and to have better understanding about pros and cons of the paleo diet.

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